Not everyone who is exposed to a carcinogen will develop cancersome people are more or less. Variables like smoking or obesity can contribute to the appearance of a cancer cluster when one actually doesn’t exist, Dr. A longitudinal analysis of a real-world cohort of MBC patients indicates that CTC-clusters analysis provides additional prognostic value to single CTC enumeration, and that CTC-cluster size correlates with patient outcome. Other factors, such as smoking, obesity and age, may make cancer clusters even more difficult to prove. Moreover, patients with CTC-cluster of a larger size were at a higher risk of death. In joint analysis, patients with high CTC counts and CTC-cluster at baseline were at a higher risk of progression and death, and longitudinal analysis showed that patients with CTC-clusters had significantly shorter survival compared to patients without clusters. Elevated CTC counts and CTC-clusters at baseline were significantly associated with a shorter survival time. Associations with progression-free survival (PFS) and overall survival (OS) were evaluated using Cox proportional hazards modelling. CTC and CTC-cluster enumeration was performed using the CellSearch ® system. Blood samples were longitudinally collected at baseline and follow up. We aim to evaluate the prognostic value of longitudinally collected single CTCs and CTC-clusters in a heterogeneous real-world cohort of 54 MBC patients. Moreover, clinical evidences show that CTC-cluster counts add prognostic information to CTC enumeration, however, their significance is not well understood, and more clinical evidences are needed. Circulating tumor cell (CTC) enumeration has emerged as a powerful biomarker for the assessment of prognosis and the response to treatment in metastatic breast cancer (MBC).
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